KEAP1 and Parkinson disease: Also, it was reported that safranal significantly inhibited the ROS generation and cell apoptosis induced by rotenone as well as toxicity and inflammation via inhibition of kelch-like ECH-associated protein 1 (Keap1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) expression in rotenone-induced dopaminergic neurons in a Parkinson’s disease model (27).