Lifestyle factors, e.g., excessive food intake and physical inactivity contribute to an increase in oxidative stress (OS) which in turn can result in the development of Type 2 diabetes mellitus (T2DM) by activating stress-signaling pathways, such as the NF-kB pathway as well as decreasing intracellular anti-oxidant defense enzymes (5). The gene discussed is NFKB1; the disease is type 2 diabetes mellitus.