Our study revealed that the expression of miR-124-3p led to the significant suppression of PIK3CA, FGFR4, and AR genes in LNCaP cells, while in PC-3 cells, it suppressed all genes except FGFR4. MiR-124-3p has been identified as a prognostic marker for PC, and its prognostic value is independent of other factors (35). The gene discussed is PIK3CA; the disease is pachyonychia congenita.