(2019) indicated that mice lacking the epigenetic regulatory enzyme enhancer of zest homolog 2 (Ezh2) presented an increased number of iNKT2 cells in association with higher levels of IgE, airway inflammation, and induced or spontaneous AHR, supporting the pathologic role of iNKT2 cells in the development of asthma (127). Here, EZH2 is linked to asthma.