Furthermore, a recent study using a murine model for asthma demonstrated that enhancing the suppressive capabilities of Treg cells through CD39 overexpression led to a lower number of pulmonary NKT cells, along with a reduced secretion of IL-4 and IFN-γ derived from these cells, causing a reduction in airway resistance, lower pulmonary eosinophilia, and reduced goblet cell hyperplasia (122). This evidence concerns the gene IL4 and asthma.