It was established that OVA-induced allergic asthma on BALB/c Cd1d−/− mice presented a significant increase in AHR, a higher number of total cells in BAL fluid, enhanced mucus metaplasia, subepithelial fibrosis, and smooth muscle hyperplasia with increased levels of IL-4 and IL-13 (132). This evidence concerns the gene IL13 and allergic asthma.