The first study addressing the possible pathogenic role of NKT cells in asthma revealed that the depletion of NK1.1+ cells, such as NK and NKT cells, before the immunization with ovalbumin (OVA) as a model of allergic asthma led to a reduction of airway eosinophilia and T cell infiltration in the lungs together with diminished levels of allergen-specific IgE (113). The gene discussed is IGHE; the disease is allergic asthma.