EED and dilated cardiomyopathy: In addition to demonstrating that epigenetically abnormal disorders can be reversed by epigenetic re-regulation, previous studies have shown that deletion of EED in cardiomyocytes contributes to the development of dilated cardiomyopathy, which may be related to the aberrant accumulation of H3K27ac (lysine residue 27 on histone H3 that undergoes acetylation) (35).