Our results showed that TGIF2 was positively correlated with Th2, macrophages, eosinophils and neutrophils, etc., while displaying a negative correlation with mast cells, NK CD56bright cells, pDC, and TFH, etc. The balance of Th1/Th2 is an important mechanism leading to immune evasion of tumors (54, 55), therefore, TGIF2-mediated Th2 enrichment may be one of the potential factors for tumor cells to evade immune surveillance. Here, TGIF2 is linked to neoplasm.