For instances, AL445490.1 and NRIR are hub genes in a module associated with interferon signaling, and these lncRNAs are also found as important interferon target genes in recent studies (14, 35); The module associated with B cells contains as hub genes TCL6 and AL139020.1, highly interconnected with the protein coding gene TCL1A, associated with pediatric B-cell acute lymphoblastic leukemia (48); In the same B cells module, but with opposite expression pattern, we highlight AL928742.1, a lincRNA closely co-expressed with TBC1D27 and TNFRSF13B (TACI). The gene discussed is NRIR; the disease is B-cell acute lymphoblastic leukemia.