For example, TXNDC5 expression is induced by three endoplasmic reticulum stress conditions, including glucose deprivation, serum deprivation and the presence of tunicamycin (TM) (143, 144), endoplasmic reticulum stress is a key factor in tumor-promoting mechanisms (144), which affect protein glycosylation and ATP production, leading to endoplasmic reticulum stress and the accumulation of unfolded or misfolded proteins. The gene discussed is TXNDC5; the disease is neoplasm.