Given the critical role of inhibition in generating tinnitus and the inhibition mediated by TRN (Steriade, 2005; Llano et al., 2012; Galazyuk et al., 2019), boosting TRN-mediated inhibition may relieve tinnitus-related hyperactivity within the central auditory system (Richardson et al., 2012). The gene discussed is TNPO1; the disease is Tinnitus.