In the context of colon cancer, the proteins cysteine aspartic acid protease-3 (caspase 3), B-cell lymphoma 2 (Bcl-2), and B-cell lymphoma-extra large (Bcl-xL) are of particular interest due to their roles in apoptosis (programmed cell death) and their potential implications in cancer progression, including colon cancer. This evidence concerns the gene CASP3 and cancer.