As a result of these changes, tumor-infiltrating CD8+ cells have a variety of functional flaws, including decreased Interleukin (IL) 2 production and lower proliferation, which can also aid in the tumor’s ability to persist [9,10]. By secreting cytokines or interacting directly with dendritic cells, NK cells are involved in both types of immune response. The gene discussed is CD8A; the disease is neoplasm.