The small ribosomal protein RPS6 and phosphorylated-RPS6 also have increased abundance in many cancers, such as ovarian cancer, esophageal squamous cell carcinoma, and non-small cell lung cancer and promotes invasive activity (Kimet al., 2013;Yanget al., 2020). This evidence concerns the gene RPS6 and esophageal squamous cell carcinoma.