For example, eIF4G and eIF4E proteins have increased expression across a variety of human cancers and inhibition of eIF4G in prostate cancer cells and eIF4E in ovarian cancer, breast cancer, and melanoma cell lines inhibits invasive activity (Jaiswalet al., 2019;Joyceet al., 2017;Nasret al., 2013;Wanet al., 2015). This evidence concerns the gene EIF4G1 and melanoma.