MAPT and Alzheimer disease: This aspect, in turn, could heighten the risk of brain amyloid β and tau pathology, ultimately leading to an elevated risk of AD and dementia (Pietrzik and Jaeger, 2008; Taguchi, 2009; Waldstein and Wendell, 2010; Correia et al., 2012; Nägga et al., 2018; Fayosse et al., 2020).