A pivotal moment in this realm was in 2011 when multiple research cohorts, almost in synchrony, pinpointed a GGGGCC hexanucleotide repeat expansion in the non-coding precinct of C9orf72 as the catalyst for chromosome 9p-linked ALS/FTD [14,15,29]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.