A study emphasized on evaluating the [3H]PK11195 binding parameters in acute inflammation model, the fMLP-stimulated neutrophil cell membranes, and analyzing if alterations of peripheral-type benzodiazepine receptor (PBR) characteristics occurred in neutrophil cell membranes of patients affected by osteoarthritis (OA), RA and psoriasic arthritis (PA). This evidence concerns the gene TSPO and osteoarthritis.