MSLN and familial pancreatic carcinoma: Schematic diagram. The effect of MSLN on EMT, cancer stem cell traits and chemotherapy resistance of pancreatic cancer cells: MSLN promoted the intercellular-matrix adhesion, proliferation, migration and invasion of pancreatic cancer cells; MSLN promoted pancreatic cancer cell EMT; MSLN promoted the cancer stem cell traits of pancreatic cancer cells; MSLN enhanced resistance of pancreatic cancer cells to gemcitabine.