The APOE4+ group showed lower levels of bilirubin than the APOE4− group in TB (Z = 2.553, p = 0.011, difference value: 4.56, and 95% CI: 1.27–7.54), DB (Z = 2.973, p = 0.003, difference value: 1.06, and 95% CI: 0.56–1.72) and IB (Z = 2.366, p = 0.018, difference value: 3.50, and 95% CI: 0.70–6.30). This evidence concerns the gene APOE and tuberculosis.