ThePIK3CAgene, located on the q26 region of the long arm of chromosome 3 (3q26), frequently undergoes activating mutations or copy number amplifications in lung cancer.18, 19, 20, 21PIK3CAis responsible for regulating the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, crucial in governing cell proliferation, adhesion, differentiation, and motility.22Activated PI3K signaling leads to increased NRF2 accumulation in the nucleus,23thereby enhancing various biological processes, including de novo purine nucleotide synthesis, glutamine metabolism, and the pentose phosphate pathway. The gene discussed is PIK3CA; the disease is lung carcinoma.