The PI3K inhibitor NVP-BKM120 reduces NRF2 expression in squamous lung cancer cells.24Diosmetin selectively induces apoptosis and enhances paclitaxel efficacy in NSCLC cells by accumulating reactive oxygen species through disrupting the PI3K/Akt/GSK-3β/Nrf2 pathway.25Recent studies have revealed the involvement of NFE2L2 in DNA repair. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.