In the isoprenaline-induced cardiac hypertrophy rat cardiomyoblast cell line (H9c2) cell models, the sEH inhibitors TUPS and 11,12-EET both reduced the expression of isoprenaline-mediated hypertrophic markers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC) (Althurwi et al., 2013). This evidence concerns the gene EPHX2 and cardiac hypertrophy.