sEH inhibitor TPPU activates the AKT/GSK3βpathway or ERK/p38 MAPK signaling pathway by elevating the level of EETs, promoting miR-126 expression, enhancing the recruitment of bone marrow-derived EPCs to the infarcted area, which in turn promotes angiogenesis and post-MI cardiac repair (Guo et al., 2018; Gui et al., 2020). Here, EPHX2 is linked to myocardial infarction.