EPHX2 and pulmonary arterial hypertension: sEH inhibitors such as ACU and AEPU as well as 11,12 -EET promote the translation of TRPC6 in pulmonary artery smooth muscle cells, increasing calcium ions into the cells, leading to smooth muscle contraction and pulmonary artery pressure increase, which is detrimental to the recovery of pulmonary hypertension (Keserü et al., 2008).