We confirmed that: (1) DBIL, Duration of medication, and ALB emerged as independent protective predictors against dyslipidemia induced by VPA in pediatric epilepsy patients, while BMI and AST were risk factors; (2) among the individual risk factors, DBIL had a stronger predictive ability compared to other factors when predicting individually; and (3) the combination of these five risk factors exhibited the strongest predictive capability compared to individual risk factors. The gene discussed is ALB; the disease is epilepsy.