In ovariectomized rats, the administration of CMD has been shown to promote osteogenesis (Tsuji-Naito, 2008), and the combined treatment with both CMD and parathyroid hormone (PTH) also has been demonstrated to enhance the therapeutic effect of PTH on glucocorticoid-induced osteoporosis in rats (Wu et al., 2018a). The gene discussed is PTH; the disease is osteoporosis.