Regarding their roles in bone disorders, UNC5B, as a downstream effector of netrin-1, has been shown to prevent bone destruction (Maruyama et al., 2016), and DCC has been reported to be expressed in a CD166-positive subpopulation of chondrocytes in human osteoarthritic cartilage (Bosserhoff et al., 2014). Here, UNC5B is linked to bone disorder.