Other representative combinations include HLA-B*58:01 linked to allopurinol-induced Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) (7–9), HLA-B*13:01 associated with dapsone-induced SCARs (10), HLA-B*15:02 related to carbamazepine-induced SJS/TEN (11, 12), and HLA-A*31:01 linked to carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (13). This evidence concerns the gene HLA-B and toxic epidermal necrolysis.