PIN1 SNPs that reduce Pin1 expression (Lu et al., 2009) are associated with increased risk for AD in an Italian cohort (Segat et al., 2007), although not in others (Nowotny et al., 2007; Ma et al., 2012) whereas a different SNP that prevents Pin1 suppression by the brain-selected AP4 is associated with delayed onset of AD (Ma et al., 2012). The gene discussed is PIN1; the disease is Alzheimer disease.