Furthermore, cerebral ischemic insults activate DAPK1, which phosphorylates Pin1 Ser71 and leads to Pin1 inhibition, cis P-tau induction, pathology, neuroinflammation and memory impairment (Sultana et al., 2006; Chen et al., 2015; Qiu et al., 2021). The gene discussed is PIN1; the disease is memory impairment.