In patients, cis P-tau is induced early in MCI neurons and is specifically induced at the dystrophic neurites of degenerating neurons (Nakamura et al., 2012), correlating well with cognitive deficits as AD progresses (Davies et al., 1987; DeKosky and Scheff, 1990; Scheff et al., 1990; Terry et al., 1991; Masliah et al., 1992; Coleman and Yao, 2003; Thies and Mandelkow, 2007). Here, MAPT is linked to Alzheimer disease.