A recent study on tularemia patients demonstrated a very sustained persistence of both IgM and IgG antibodies, and significant decreases of IgG titers did not occur until 12 months after onset of disease and of IgM at 4 months after onset, but both IgG and IgM average titers still were above cutoff values at 12 months (Lindgren et al., 2022). The gene discussed is CD40LG; the disease is tularemia.