In animal models, EPO exhibited cardioprotective activity in ischemia-reperfusion injury of isolated adult hearts (Cai et al., 2003; Parsa et al., 2003), and in vivo, in myocardial infarction, long-term EPO treatment induced neovascularization (Cai and Semenza, 2004; van der Meer et al., 2005; Westenbrink et al., 2010). This evidence concerns the gene EPO and myocardial infarction.