Among hypertrophic cardiomyopathy-related genes, high phenotypic expression of Myh7 affects the myocardial mechanical function (de Frutos et al., 2022), Nppa expression reactivated in the ventricles is a marker of heart disease (Horsthuis et al., 2008), and elevated BNP (Nppb) is a hallmark of heart failure (Sangaralingham et al., 2023). Here, NPPA is linked to heart failure.