Sarcomere dysfunction contributes significantly to heart failure and includes, for example, genetic mutations in myomesin 2 (Myom2) located in the M line, middle of the sarcomere, and provides structural integrity, myozenin 2 (Myoz2) located in the Z line and regulates calcium-dependent signaling pathways, and possibly Tcap also in the Z-line (Sequeira et al., 2014; Martin et al., 2021). The gene discussed is MYOZ2; the disease is heart failure.