NPRL3 and Pelizeaus-Merzbacher spectrum disorder: Based on the phenotypic characteristics of mutant lines, it can be inferred that rmd1-1, rmd1-2, rmd1-3, 4000, 4200, 4800, 5000, 5100, and 5300 lines exhibit susceptibility to PMD, while the mutant lines of other candidate genes, such as 3800 and 5400, are resistant to PMD (Figure 9A).