Hawthorn alleviated FD by significantly reducing the gastric residual rate, increasing the intestinal propulsion rate, increasing the intake of food and drinking water, increasing the levels of gastrointestinal hormones, upregulating SP and 5-HT expression in the duodenum, and downregulating the serum NO levels and VIP expression in the duodenum. The gene discussed is TFF2; the disease is Fabry disease.