Compared to the CTL group, the small intestinal propulsion rate significantly decreased (p < 0.01), the serum NO levels significantly increased (p < 0.05), the GAS levels significantly decreased (p < 0.05), the VIP levels in the duodenal homogenate significantly increased (p < 0.01), and the SP and 5-HT levels significantly decreased (p < 0.01) in the FD group. The gene discussed is VIP; the disease is Fabry disease.