The overweight/obese state influences metabolic dysfunction (Lassale et al., 2018) and is associated with AST/ALT ratio (AST)/alanine aminotransferase (ALT) ratio in coronary/arterial heart diseases (Liu & Liu, 2022), nonalcoholic liver disease (NAFLD) (Harrison et al., 2008), and alterations in the microbiome composition (Dreyer & Liebl, 2018; Liu et al., 2021). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.