IOP‐A2 could significantly reduce lipid accumulation and the level of TC and TG in HepG2 steatosis induced by OA, and it may play a hypolipidemic role mainly through the promotion of cholesterol transformation and regulation of cholesterol metabolism‐related proteins such as CYP7A1, LXRα, SR‐B1, and ABCA1. The gene discussed is NR1H3; the disease is steatosis.