The results showed that IOP‐A could significantly reduce liver and spleen indexes, limit the fatty degeneration of the liver, lower TC, TG, LDL‐C, AST, and ALT levels, increase HDL‐C levels, and up‐regulate CYP7A1 and SR‐B1 protein expression in the liver of hyperlipidemic rats. Here, SCARB1 is linked to digestive system neoplasm.