It was also found that low doses of resveratrol inhibited the proliferation of non‐small cell lung cancers A549 and H460 mainly through a non‐mitochondrial pathway, activating NAPDH oxidase (NOX‐5) to produce ROS and inducing upregulation of p53 and p21 genes, which in turn affected cellular DNA damage (Luo et al., 2013). The gene discussed is NOX5; the disease is lung cancer.