FMO5 and lung cancer: It was also found that low doses of resveratrol inhibited the proliferation of non‐small cell lung cancers A549 and H460 mainly through a non‐mitochondrial pathway, activating NAPDH oxidase (NOX‐5) to produce ROS and inducing upregulation of p53 and p21 genes, which in turn affected cellular DNA damage (Luo et al., 2013).