In the SA‐treated and Met‐treated PCOS groups, the levels of Smad7 proteins were notably higher than those in the PCOS group (p < .01 and p < .05, respectively), with a more marked increase observed in the SA‐treated PCOS rats than in the Met‐treated PCOS rats (p < .01). This evidence concerns the gene SMAD7 and polycystic ovary syndrome.