We identified several key genes, including those coding for canonical DAMPs such as CLAR and HMGB1, as well as IFNB1, IFNG, CD8A, CD8B, CXCR3, FOXP3, BAX, IL6, and PRF1, which were dysregulated in most cancers and possessed significant prognostic value. This evidence concerns the gene PRF1 and cancer.