CD274 and cancer: Additionally, GSEA revealed that a high ICD score was positively associated with six hallmark pathways, namely the NF‐kappa B signaling pathway, PD‐L1 expression and PD‐L1 checkpoint pathway in cancer, JAK–STAT signaling pathway, cell adhesion molecules, NOD‐like receptor signaling pathway, and Toll‐like receptor signaling pathway (Figure 8E).