Similar to previous reports [38] where 75% of deaths had sepsis (n = 15 out of 20 deaths), 100% of HI patients who died in our study suffered sepsis (n = 4 out of 4), while 75% of total HI patients experienced sepsis (n = 6 out of 8); 4 HI patients had novel mutations in ABCA12, mostly truncating, resulting in the loss of the ABC2 domain of the ATP Binding Cassette Subfamily A Member 12. Here, ABCA12 is linked to Sepsis.