Selected loci have been described in recent CAD-related GWASs, and the mechanism of action for several of them has been linked either with lipid levels (LDLR, SORT1, and LPA) or with molecular changes within the vascular wall implicated in atherosclerosis (CDKN2A/B, FES/FURIN, PHACTR1) (Additional file 1: Tables S2 and S3). This evidence concerns the gene SORT1 and atherosclerosis.