Presence of ANA (p = 0.000) and RF (p = 0.017) were significantly lower in seronegative pSS, while no significant differences were detected in other autoantibodies such as anti-CCP, anti-dsDNA, anti-histones, anti-nucleosome, anti-U1nRNP/Sm, anti-Rib, anti-Sm, anti-Jo1, anti-CENPB, anti-ANCA, anti-aCL and anti-β2-GP1 (partial data not shown in Table 2). This evidence concerns the gene ACLY and peeling skin syndrome.