TREM2 and Cognitive impairment: Epimedii Folium and Curculiginis Rhizoma, extracts of Horny Goat Weed and Xianmao, enhance TREM2 protein expression in the hippocampus by reducing TNF-α and IL-1β, regulating the transformation and activation of microglial cells, thus improving LPS-induced cognitive impairments [260].