Bilberry anthocyanins (BA) lowered serum and brain LPS levels, increased SCFAs in feces, induced microglial phagocytosis of Aβ through the CD33/TREM2/TYROBP signaling pathway, alleviated hippocampal neuroinflammation, and reversed cognitive impairments in APP/PS1 mice [254]. Here, TREM2 is linked to Cognitive impairment.