MAPT and Cognitive impairment: It enhances the abundance of anti-inflammatory microbial groups, such as Firmicutes and Lactobacillus, suppresses the activation of the C/EBPβ/AEP pathway, alleviates Aβ plaque deposition, tau hyperphosphorylation, and neuroinflammation, ultimately improving cognitive deficits in TgCRND8 mice [256].