TIMP1 and Vascular dilatation: It is supported by the evidence that women presented increased expression of matrix metalloproteinase 2 and 9 and decreased expression of metalloproteinase inhibitor 1 and 2 in tissues in aneurysmal disease, thus leading to increased extracellular matrix destruction in women, further resulting in greater aortic wall stiffness and pulsatile arterial load [10].