We then performed cologenic assays to further evaluate the sensitivity of the cells to PARPi and found that OLA slightly reduced the colony formation of Brca1+/+;Gata3+/+ tumor cells but significantly inhibited the colony formation of Brca1+/− or Gata3+/− tumor cells (Fig. 7f, Additional file 1: Fig. S8). The gene discussed is BRCA1; the disease is neoplasm.