While old age (p = 0.0002), stage III (p = 0.0002), Testin low expression (p < 0.0001), T3-T4 (p = 0.0042), N1-N3 (p = 0.001), invasion (p = 0.0055), group of PRISm or COPD (p = 0.0264) were associated with poor prognosis for overall survival (OS) (Table 3). The gene discussed is TES; the disease is chronic obstructive pulmonary disease.