Furthermore, multivariate Cox regression analysis revealed that age (HR = 1.041; 95%CI = 1.021–1.064; p < 0.0001), Testin expression (HR = 0.156; 95%CI = 0.101–0.241; p < 0.0001), Ki-67 expression (HR = 1.624; 95%CI = 1.120–2.354; p = 0.0106), invasion (HR = 1.866; 95%CI = 1.281–2.720; p = 0.0012) and group of PRISm or COPD (HR = 1.291; 95%CI = 1.056–1.577; p = 0.0126) were independent prognostic factors for disease free survival (DFS) (Table 4). Here, MKI67 is linked to chronic obstructive pulmonary disease.