Our previous study demonstrated that sepsis-triggered activation of the canonical nucleotide-binding domain-like receptor protein 3 (NLRP3)-caspase-1 inflammasome cleaves GSDMD in the hippocampus, initiating neuronal pyroptosis and neuroinflammation, leading to hippocampus-dependent memory impairments [10]. Here, NLRP3 is linked to memory impairment.