In addition, SOAT1 and SREBF2, two key regulators of cholesterol metabolism, were also significantly upregulated in m6A-gene-cluster A (Fig. 4E).M6A-gene-cluster A exhibited a higher expression of fatty acid biosynthetic process and a lower expression of fatty acid oxidation (Fig. 4F and G), causing fatty acid accumulation and promoting proliferation and migration of HCC cell. This evidence concerns the gene SREBF2 and hepatocellular carcinoma.