SOAT1 and hepatocellular carcinoma: In addition, SOAT1 and SREBF2, two key regulators of cholesterol metabolism, were also significantly upregulated in m6A-gene-cluster A (Fig. 4E).M6A-gene-cluster A exhibited a higher expression of fatty acid biosynthetic process and a lower expression of fatty acid oxidation (Fig. 4F and G), causing fatty acid accumulation and promoting proliferation and migration of HCC cell.