We reported for the first time the pathophysiology characterization of plasma biomarkers, Aβ PET, tau PET, hippocampal atrophy, and AD-signature cortical thinning, as well as the prevalence of Aβ PET positivity in a Chinese community aging cohort in the Guangdong-Hong Kong-Macao Greater Bay Area of China. This evidence concerns the gene MAPT and Alzheimer disease.