The GHABS project aims to: (1) explore the risk factors of Aβ and tau aggregation in the early stage of AD among China’s aging population; (2) determine the effect of Aβ and tau pathologies upon downstream neurodegeneration and cognitive decline in both Aβ negative (Aβ-) and Aβ positive (Aβ+) elderly adults; (3) identify novel approaches and techniques for early detection of AD and provides significant reference for the target brain region and appropriate time window for anti-AD treatments. Here, MAPT is linked to Alzheimer disease.