PSCA and neoplasm: The function of PSCA in GBC or gallbladder cancer is down-regulation, and its overexpression in this cancer is associated with tumor differentiation, metastasis, tumor stage and survival time [106], so this may serve as a marker to detect tumor progression and patient survival rate, while PSCA haplotypes (T rs2294008–G-rs2978974) increases gallbladder cancer in women and therefore may be effective in screening processes.