Since we have demonstrated the alteration of PIEZO expressions in irreversible pulpitis, we then utilized Spearman’s correlation analysis and found that PIEZO1 mRNA expression was significantly and positively correlated with IL1B (R = 0.5607, P = 0.0322, moderate), TNFA (R = 0.7679, P = 0.0013, strong), and IL6 (R = 0.6250, P = 0.0148, moderate), but PIEZO2 was not significantly correlated with IL1B, TNFA, or IL6 (Fig. 3D-F). Here, IL6 is linked to pulpitis.