According to somatic mutation analysis, in the two cohorts (TCGA-LAML and Beat AML), FLT3, DNMT3A, NPM1, TP53, and RUNX1 mutations were most likely to occur in the high-risk group, and the mutated genes in the low-risk group mainly included FLT3, NPM1, CEBPA, TET2, IDH2, and WT1 (Fig. 8E). The gene discussed is NPM1; the disease is acute myeloid leukemia.