CD274 and neoplasm: The study results revealed that regardless of tumor PD-L1 expression, AK104 achieved efficacy (ORR, 33.0%; CR, 12.0%; mOS, 17.5 months) and safety (grade ≥ 3 TRAEs, 28.8%) that were comparable to those of second-line therapies for recurrent/metastatic cervical cancer.