The study reported on patients having NSCLC with EGFR ex20ins mutations who were treated with the RP2D of 1050 mg of amivantamab (1400 mg for those weighing ≥ 80 kg; once per week [qw] during the first 4 weeks, followed by once every 2 weeks [q2w] starting from the 5th week). This evidence concerns the gene EGFR and non-small cell lung carcinoma.