Zenocutuzumab (MCLA-128) is a HER2/HER3-targeting BSAB that functions by docking and blocking the structural domains of these proteins, thereby preventing the binding of NRG1-HER3 ligands and NRG1 fusion proteins and subsequently disrupting the downstream signaling pathways to produce an anti-tumor effect. This evidence concerns the gene NRG1 and neoplasm.