TGFB1 and neoplasm: The mechanism of bintrafusp alfa involves several key effects including: (1) impeding or reversing TGF-β-induced EMT in tumor cells, (2) changing the NK and T cell phenotypes to augment their capacity to kill tumors, (3) eliciting ADCC to enhance tumor lysis, (4) diminishing Treg activity, and (5) increasing the sensitivity of tumors to chemotherapeutic agents [188].