In this study, the presence of human CRP was associated with significantly decreased insulin-stimulated glycogenesis in skeletal muscle, increased insulin plasma levels, increased muscle and hepatic accumulation of TAG and decreased plasmatic cGMP concentrations, reduced adiponectin levels and increased monocyte chemoattractant protein-1 (MCP-1) levels in the blood, suggesting pro-inflammatory effects and presence of multiple features of metabolic syndrome in SHR-CRP animals as was partially shown previously [13]. This evidence concerns the gene ADIPOQ and metabolic syndrome.