According to a study utilizing single-cell sequencing data to explore the immunogenicity of ascending thoracic aortic aneurysm, it was found that NK cells communicate with endothelial cells through the CXCL12-CXCR4 and CCL5-ACKR1 axes [20]. The gene discussed is CXCL12; the disease is thoracic aortic aneurysm.