increase in plasma IGFBP1 levels in early pregnancy was associated with a greater than 50% reduction in the risk for GDM in Gen3G (OR = 0.44; IQR = 0.30–0.64; P < 0.001; adjusted for maternal age, gravidity, gestational age at plasma IGFBP1 measurements and maternal BMI; Table 3). Here, IGFBP1 is linked to gestational diabetes.