Our ROC analyses showed that circulating IGFBP1 levels in early pregnancy have a predictive ability beyond that of established GDM risk factors (including maternal BMI and family history of diabetes); however, the moderate ROC AUC value in a model that included IGFBP1 levels along with these clinical factors suggests that additional biomarkers would be necessary for clinical utility. The gene discussed is IGFBP1; the disease is gestational diabetes.