IGFBP1 and diabetes mellitus: Prediction analyses were conducted using plasma IGFBP1 measured in early pregnancy (median 9 weeks gestation) and GDM (diagnosed with International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria applied to a 75g-OGTT at a median of 26 weeks gestation) in Gen3G participants (n = 837) in addition to known clinical risk factors.