Although AKE was classified as type III punctate palmoplantar keratoderma (PPKP3) in 1996 [7], some pathogenesis elements of palmoplantar keratoderma, such as the AAGAB gene in type I palmoplantar keratoderma (PPKP1), have been found not to be involved in AKE [8]. This evidence concerns the gene AAGAB and punctate palmoplantar keratoderma type III.